STABILIZATION OF DNA-DNA AND DNA-RNA DUPLEXES BY SUBSTITUTION OF 2'-DEOXYADENOSINE WITH 2'-DEOXY-2-AMINOADENOSINE

Authors
GRYAZNOV S SCHULTZ RG
Citation
S. Gryaznov et Rg. Schultz, STABILIZATION OF DNA-DNA AND DNA-RNA DUPLEXES BY SUBSTITUTION OF 2'-DEOXYADENOSINE WITH 2'-DEOXY-2-AMINOADENOSINE, Tetrahedron letters, 35(16), 1994, pp. 2489-2492
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
16
Year of publication
1994
Pages
2489 - 2492
Database
ISI
SICI code
0040-4039(1994)35:16<2489:SODADD>2.0.ZU;2-5
Abstract
Oligonucleotides containing either 2'-deoxyadenosine d(A) or 2'-deoxy- 2-aminoadenosine d(A) were synthesized and their relative binding aff inities to complementary DNA and RNA targets compared. Substitution of dA with dA resulted in sequence- and target-dependent changes in dup lex stability.