C-14 LABELING OF THE NEW ANTIASTHMATIC FL EZELASTINE

Authors
ENGEL J BORK A FLEISCHHAUER I KUTSCHER B LIEFLANDER M
Citation
J. Engel et al., C-14 LABELING OF THE NEW ANTIASTHMATIC FL EZELASTINE, Journal fur praktische Chemie, Chemiker-Zeitung, 336(3), 1994, pp. 207-210
Citations number
13
Categorie Soggetti
Chemistry,"Chemistry Applied
Journal title
Journal fur praktische Chemie, Chemiker-Zeitung → ACNP
ISSN journal
09411216
Volume
336
Issue
3
Year of publication
1994
Pages
207 - 210
Database
ISI
SICI code
0941-1216(1994)336:3<207:CLOTNA>2.0.ZU;2-3
Abstract
Flezelastine is a new phthalazinone derivative with antiasthmatic/anti allergic activity. For pharmacokinetic studies C-14-labeled flezelasti ne was synthesized starting with [7,8-C-14]-phthalic anhydride. In a c onvergent synthesis 1.5 g of double C-14-labeled flezelastine hydrochl oride (ASTA code: D-18024) with a specific activity of 3 MBq/mg was ob tained.