INVESTIGATION OF THE CYCLODEXTRIN COMPLEXES OF MANDELIC-ACID DERIVATIVES

Racemic free mandelic acid and its methyl, ethyl, isoamyl and benzyl e sters were found to form inclusion complexes with all the three studie d natural cyclodextrins proved by thermoanalytical results. Difference s between the solid state stability of guests were detected mainly by evolved gas analysis. Even signs of an eventual optical resolution by molecular inclusion were observed in several cases, but still not suff iciently proven. Due to the rather high volatility and low melting poi nts of the majority of guest substances DSC technique was found to be suitable for studying the cyclodextrin complexes of mandelic acid.