THE DEVELOPMENT OF NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - ASUCCESS STORY

Authors
HOLTJE HD JESSEN G HOLTJE M
Citation
Hd. Holtje et al., THE DEVELOPMENT OF NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - ASUCCESS STORY, Die Pharmazie, 52(2), 1997, pp. 83-86
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
52
Issue
2
Year of publication
1997
Pages
83 - 86
Database
ISI
SICI code
0031-7144(1997)52:2<83:TDONAR>2.0.ZU;2-I
Abstract
The modulation of the renin-angiotensin system continues to be an impo rtant target in drug design. The development of nonpeptide angiotensin II receptor antagonists offers a new tool in treatment of hypertensio n. Starting from benzimidazole lead structures detailed structure-acti vity analyses, molecular modeling methods, and dedicated syntheses led to the development of potent, orally active antihypertensive drugs.