SYNTHESIS, STRUCTURES AND BIOLOGICAL-ACTIVITY OF SOME 4-AMINO-3-CINNOLINE-CARBOXYLIC ACID-DERIVATIVES .2.

Authors
STANCZAK A LEWGOWD W OCHOCKI Z PAKULSKA W SZADOWSKA A
Citation
A. Stanczak et al., SYNTHESIS, STRUCTURES AND BIOLOGICAL-ACTIVITY OF SOME 4-AMINO-3-CINNOLINE-CARBOXYLIC ACID-DERIVATIVES .2., Die Pharmazie, 52(2), 1997, pp. 91-97
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
52
Issue
2
Year of publication
1997
Pages
91 - 97
Database
ISI
SICI code
0031-7144(1997)52:2<91:SSABOS>2.0.ZU;2-6
Abstract
6,7,8-Substituted 4-amino-3-cinnolinecarboxylic acids 1 were condensed with amines to the corresponding 4-amino-3-cinnolinecarboxamides 7,8. A variety of pharmacological tests showed a significant CNS activity of some new amides. Decarboxylation of 4-amino-3-cinnolinecarboxylic a cids 1 yielded the corresponding 4-aminocinnolines 4 and alkaline hydr olysis of 1 gave 4-oxo-3-cinnolinecarboxylic acids 2. The acids 1 were converted into pyrimido[5,4-c]cinnolines 6 on two ways of synthesis.