USE OF 1,3-DIOXIN-4-ONES AND RELATED-COMPOUNDS IN SYNTHESIS .44. ASYMMETRIC ALDOL REACTION OF 4-TRIMETHYLSILOXY-6-METHYLENE-1,3-DIOXINES - USE OF TARTARIC ACID-DERIVED (ACYLOXY)BORANE COMPLEX AS THE CATALYST

Authors
SATO M SUNAMI S SUGITA Y KANEKO C
Citation
M. Sato et al., USE OF 1,3-DIOXIN-4-ONES AND RELATED-COMPOUNDS IN SYNTHESIS .44. ASYMMETRIC ALDOL REACTION OF 4-TRIMETHYLSILOXY-6-METHYLENE-1,3-DIOXINES - USE OF TARTARIC ACID-DERIVED (ACYLOXY)BORANE COMPLEX AS THE CATALYST, Chemical and Pharmaceutical Bulletin, 42(4), 1994, pp. 839-845
Citations number
30
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
4
Year of publication
1994
Pages
839 - 845
Database
ISI
SICI code
0009-2363(1994)42:4<839:UO1ARI>2.0.ZU;2-Y
Abstract
A novel enantioselective synthesis of 1,3-dioxin-4-ones having a 2-hyd roxylated alkyl group at the 6-position has been accomplished by chira l tartaric acid-derived acylborane-mediated aldol condensation of the silyl enol ether derived from 6-methyl-derivatives of 1,3-dioxin-4-one with achiral aldehydes.