A STABLE MONOSUBSTITUTED ISOINDOLE DERIVATIVE - THE CRYSTAL-STRUCTUREOF BENZOTRIAZOL-1-YL)-2-(4-METHYLPHENYL)-2H-ISOINDOLE

Authors
TAKAHASHI I TSUZUKI M KEUMI T KITAJIMA H ISA K HOSOI S TSUDA Y
Citation
I. Takahashi et al., A STABLE MONOSUBSTITUTED ISOINDOLE DERIVATIVE - THE CRYSTAL-STRUCTUREOF BENZOTRIAZOL-1-YL)-2-(4-METHYLPHENYL)-2H-ISOINDOLE, Chemical and Pharmaceutical Bulletin, 42(4), 1994, pp. 947-949
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
4
Year of publication
1994
Pages
947 - 949
Database
ISI
SICI code
0009-2363(1994)42:4<947:ASMID->2.0.ZU;2-T
Abstract
benzotriazol-1-yl)-2-(4-methylphenyl)-2H-isoindole (1a) is a stable is oindole derivative in the crystalline state. On the basis of the resul ts of X-ray crystallographic analysis, this exceptional stability was explained as follows: the presence of a typical anti-parallel face-to- face stacking between isoindole rings deprives the two reactive center s of an intermolecular approach.