A NOVEL METHOD FOR THE PREPARATION OF CONTROLLED-RELEASE THEOPHYLLINECAPSULES COATED WITH A POLYELECTROLYTE COMPLEX OF KAPPA-CARRAGEENAN AND CHITOSAN

Authors
TOMIDA H NAKAMURA C KIRYU S
Citation
H. Tomida et al., A NOVEL METHOD FOR THE PREPARATION OF CONTROLLED-RELEASE THEOPHYLLINECAPSULES COATED WITH A POLYELECTROLYTE COMPLEX OF KAPPA-CARRAGEENAN AND CHITOSAN, Chemical and Pharmaceutical Bulletin, 42(4), 1994, pp. 979-981
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
4
Year of publication
1994
Pages
979 - 981
Database
ISI
SICI code
0009-2363(1994)42:4<979:ANMFTP>2.0.ZU;2-M
Abstract
A novel method for the preparation of kappa-carrageenan/chitosan polye lectrolyte complex (PEC) membrane capsules containing theophylline as a model drug was developed. The theophylline release from the capsules followed zero-order kinetics, and the release rates were independent of pH of the dissolution medium, suggesting that kappa-carrageenan/chi tosan PEC capsules could be a useful vehicle for controlled-release dr ug delivery.