TOTAL SYNTHESIS OF A NOVEL IMMUNOSUPPRESSANT, MYRIOCIN (THERMOZYMOCIDIN, ISP-I), AND Z-MYRIOCIN

Authors
YOSHIKAWA M YOKOKAWA Y OKUNO Y MURAKAMI N
Citation
M. Yoshikawa et al., TOTAL SYNTHESIS OF A NOVEL IMMUNOSUPPRESSANT, MYRIOCIN (THERMOZYMOCIDIN, ISP-I), AND Z-MYRIOCIN, Chemical and Pharmaceutical Bulletin, 42(4), 1994, pp. 994-996
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
4
Year of publication
1994
Pages
994 - 996
Database
ISI
SICI code
0009-2363(1994)42:4<994:TSOANI>2.0.ZU;2-R
Abstract
Myriocin (thermozymocidin, ISP-I), which was known to exhibit several interesting biological properties such as potent immunosuppressive and antifungal activities, and a new analog Z-myriocin were synthesized f rom 2-deoxy-D-glucose, This synthetic pathway comprises a stereoselect ive formation of the chiral alpha, alpha-disubstituted amino acid stru cture in myriocin and Z-myriocin from the isopropylidene six-menbered ketone by using a modified Darzen reaction as its key step.