EPIDERMAL GROWTH-FACTOR RECEPTOR EXPRESSION IN MURINE COLONIC CARCINOGENESIS

Citation
S. Carraro et al., EPIDERMAL GROWTH-FACTOR RECEPTOR EXPRESSION IN MURINE COLONIC CARCINOGENESIS, Journal of experimental & clinical cancer research, 13(1), 1994, pp. 57-60
Citations number
NO
Categorie Soggetti
Oncology
ISSN journal
03929078
Volume
13
Issue
1
Year of publication
1994
Pages
57 - 60
Database
ISI
SICI code
0392-9078(1994)13:1<57:EGREIM>2.0.ZU;2-V
Abstract
The influence of the duodenal medium, particularly rich in epidermal g rowth factor, in a colonic segment interposed within the duodenum (ICS ) has been evaluated. We have also determined the epidermal growth fac tor receptor (EGFR) content in colon carcinomas. Rats were divided in 3 groups: interposed colon segment to the duodenum, sham operated, con trol. Half of the animals have received dimethylhydrazine for 12 weeks . Animals were killed at 2, 4, 8 months. At 8 months, EGFR content was 1.12 +/- 2.2 fmol/mg for ICS tumors and 28.74 +/- 10 fmol/mg in left colon carcinomas (p < 0.01). The biological implication of these findi ngs is discussed.