Twelve patients with Graves' ophthalmopathy (grade 1-6, ATA classifica
tion) were treated with Cyclosporin-A, systemically in combination wit
h methylprednisolone. We observed slight or moderate favourable effect
in 9 cases. Our data suggest that the benefit was due to the methylpr
ednisolone, the effectivity of which was enhanced by the cyclosporin e
ven in the glucocorticoid-resistant cases.