MAPPING OF THE GENE FOR DOMINANT PALMOPLA NTARIS HYPERKERATOSIS (TYLOSIS) ON CHROMOSOME 17Q12-Q24

Authors
ROGAEV EI ROGAEVA EA GINTER EK KOROVAITSEVA GI FARRER LA SHLENSKII AB PRYTKOV AN STGEORGEHYSLOP PH MORDOVTSEV VN
Citation
Ei. Rogaev et al., MAPPING OF THE GENE FOR DOMINANT PALMOPLA NTARIS HYPERKERATOSIS (TYLOSIS) ON CHROMOSOME 17Q12-Q24, Genetika, 30(3), 1994, pp. 326-329
Citations number
11
Categorie Soggetti
Genetics & Heredity
Journal title
Genetika → ACNP
ISSN journal
00166758
Volume
30
Issue
3
Year of publication
1994
Pages
326 - 329
Database
ISI
SICI code
0016-6758(1994)30:3<326:MOTGFD>2.0.ZU;2-U
Abstract
Mapping of the genetic defect causing dominant palmoplantaris hyperker atosis (PPHK) was continued based on the material of an extended Uzbek pedigree. No linkage between the PPHK gene and hypervariable DNA mark ers from 8p, 12p, 14q, and 22q were revealed. The study of PPHK gene t o 17q12-q24 and revealed close linkage with KRT10 and D17S800 loci (ze ro recombination frequency at a lod score > 7). The possible location of a PPHK mutation in one of the keratin genes mapped to the same regi on on the 17th chromosome is discussed.