REVERSIBILITY OF CEREBRAL-ISCHEMIA DYNAMIC AND XENON COMPUTED-TOMOGRAPHY STUDY ON ISCHEMIC CEREBROVASCULAR-DISEASE

Flow studies using dynamic CT and xenon (Xe) CT were carried out in 25 patients with ischaemic stroke in the territory of the middle cerebra l artery to define the clinical characteristics of cerebral ischaemia at a chronic stage. The parameter of peak height/mean transit time (PH /MTT) obtained from dynamic CT can provide an accurate index for blood circulation in the cerebral vascular bed. Xe CT measurements revealed various kinds of ischaemia around the infarction even in the chronic stages. In mild ischaemia of more than 30 ml/100 g/min, reduction of c erebral blood flow (CBF) was well correlated to the PH/MTT. However, i n severe ischaemia between 20 and 30 ml/100 g/min, changes of CBF were no longer correlated with the PH/MTT. There were cases showing severe reduction of CBF but which showed sufficient blood circulation (moder ate value of PH/MTT). Mild reductions of CBF in parallel with decrease d blood supply were often found in the peri-infarct area of infarction s in the centrum semiovale. On the other hand, infarctions in the cort ico-subcortical region showed severe ischaemia, in even where blood ci rculation was relatively well sustained.