Of splenectomies performed in the Cork Regional Hospital over an 11 ye
ar period, ten were undertaken primarily for diagnostic purposes. A de
finitive histological diagnosis was established in nine patients, seve
n of whom had lymphoma, two with Hodgkin's disease and five with non-H
odgkin's lymphoma. The weight of the excised spleen in all patients wi
th lymphoma exceeded 1 kg; in all those with a diagnosis other than ly
mphoma, the spleen weighed less than 1 kg. A majority of patients also
had symptomatic improvement from reversal of hypersplenism and from r
elief of the mechanical pressure effects of an enlarged spleen. Operat
ive mortality was zero. Diagnostic splenectomy is a worthwhile procedu
re. Most patients will have lymphoma.