CHLOROQUINE-RESISTANT PLASMODIUM-FALCIPARUM IN COASTAL TANZANIA - A CHALLENGE TO THE CONTINUED STRATEGY OF VILLAGE BASED CHEMOTHERAPY FOR MALARIA CONTROL

An in vivo study to assess Plasmodium falciparum sensitivity to chloro quine was conducted in two villages of the Bagamoyo District, Tanzania in December 1992. The WHO standard field test (7 days) and the extend ed test (28 days) were carried out on symptom free children. The prese nce of chloroquine resistance was confirmed with 59 % of infections be ing found resistant. Fifty-three percent were R(I), 2 % were at R(II) and 4 % at R(III) levels of resistance. Dosage was 25 mg/kg chloroquin e base delivered over three days.