MINOCYCLINE-INDUCED PNEUMONITIS WITH BILATERAL HILAR LYMPHADENOPATHY AND PLEURAL EFFUSION

A 65-year-old man developed respiratory failure with diffuse interstit ial shadow, bilateral pleural effusion, and bilateral hilar lymphadeno pathy on chest X-ray and CT, after intravenous administration of minoc ycline. Corticosteroid therapy was effective. The findings from bronch oalveolar lavage (BAL) and transbronchial lung biopsy were compatible with eosinophilic pneumonia. Provocation test supported this diagnosis , but the lymphocyte stimulation test was negative. A review of the li terature and the diagnoses of drug-induced pulmonary diseases are disc ussed.