IMMUNOLOGICAL AND CHEMICAL STUDIES IN THE TUFTSIN-KENTSIN GROUP

The influence of tuftsin, kentsin and their two tetrapeptide analogues with the same amino acid composition, but different sequences, on the humoral and cellular immune response was examined. The immunological activity of five tripeptide fragments of the tetrapeptides mentioned a bove and, for the most active tripeptide (KRP), of its analogues with D-amino acid residues as well as the analogues with protected terminal groups was also tested. An attempt was made to correlate the biologic al activities of the peptides with their conformational properties est imated by CD measurements.