As recently demonstrated, spin saturation effects in 3D time-of-flight
(TOF) MR angiography (MRA) can be reduced by using RF pulses with lin
early increasing flip angles (ramp pulses) in the main direction of fl
ow. We developed a model for calculating the signal distribution of pr
oton flow within the excitation volume (slab) for different ramp slope
s and compared the results with the measured distribution for the lowe
r-leg arteries. The ramp pulses were generated using the Fourier trans
formation of the desired excitation profiles. With a bandwidth of 6 kH
z and a pulse length of 2.56 ms satisfactory ramps with variable slope
s were generated and applied in a standard flow-compensated 3D FISP se
quence. The effects on the signal distribution in the resulting angiog
rams of the lower limbs revealed a considerable reduction of saturatio
n losses in agreement with the calculations. Calculated optimal ramp s
lopes are provided for flow Velocities ranging from 5 to 50 cm/s and e
xcitation Volumes ranging from 5 to 25 cm.