3-DEAZAPURINES AND 7-DEAZAPURINES - DUPLEX STABILITY OF OLIGONUCLEOTIDES CONTAINING MODIFIED ADENINE OR GUANINE BASES

Authors
GREIN T LAMPE S MERSMANN K ROSEMEYER H THOMAS H SEELA F
Citation
T. Grein et al., 3-DEAZAPURINES AND 7-DEAZAPURINES - DUPLEX STABILITY OF OLIGONUCLEOTIDES CONTAINING MODIFIED ADENINE OR GUANINE BASES, Bioorganic & medicinal chemistry letters, 4(8), 1994, pp. 971-976
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
8
Year of publication
1994
Pages
971 - 976
Database
ISI
SICI code
0960-894X(1994)4:8<971:3A7-DS>2.0.ZU;2-F
Abstract
Oligonucleotide duplexes were destabilized when the purine bases of 2' -deoxyadenosine or 2'-deoxyguanosine were replaced by the correspondin g 3-deazapurine (imidazo[4,5-c]pyridine) or 7-deazapurine (pyrrolo[2,3 -d]pyrimidine) derivatives. Only d(AT)(6) was stabilized by incorporat ion of c A when high salt condition were used. The stability of deazap urine base-protecting groups was also investigated.