OPTIMIZATION OF HYBRIDIZING ABILITIES AND NUCLEASE RESISTANCE IN THE DESIGN OF CHIMERIC ALPHA-ANOMERIC OLIGODEOXYNUCLEOTIDES CONTAINING BETA-ANOMERIC GAPS

Authors
DEBART F TOSQUELLAS G RAYNER B IMBACH JL
Citation
F. Debart et al., OPTIMIZATION OF HYBRIDIZING ABILITIES AND NUCLEASE RESISTANCE IN THE DESIGN OF CHIMERIC ALPHA-ANOMERIC OLIGODEOXYNUCLEOTIDES CONTAINING BETA-ANOMERIC GAPS, Bioorganic & medicinal chemistry letters, 4(8), 1994, pp. 1041-1046
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
8
Year of publication
1994
Pages
1041 - 1046
Database
ISI
SICI code
0960-894X(1994)4:8<1041:OOHAAN>2.0.ZU;2-Y
Abstract
Various chimeric oligonucleotides consisting of alpha- and beta-anomer ic deoxynucleotide units have been synthesized and their hybridizing a bilities to complementary DNA or RNA single strands, and their stabili ty in cell culture medium or cell extracts, were studied. The results provide guide lines for optimization of antisense chimeric oligodeoxyn ucleotides.