SEQUENCE-SPECIFIC MODIFICATION OF DNA FRAGMENTS BY OLIGONUCLEOTIDE DERIVATIVES CONTAINING ALKYLATING GROUPS AT THE C5 POSITION OF DEOXYURIDINE

Authors
KHALIMSKAYA LM LEVINA AS ZARYTOVA VF
Citation
Lm. Khalimskaya et al., SEQUENCE-SPECIFIC MODIFICATION OF DNA FRAGMENTS BY OLIGONUCLEOTIDE DERIVATIVES CONTAINING ALKYLATING GROUPS AT THE C5 POSITION OF DEOXYURIDINE, Bioorganic & medicinal chemistry letters, 4(8), 1994, pp. 1083-1088
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
8
Year of publication
1994
Pages
1083 - 1088
Database
ISI
SICI code
0960-894X(1994)4:8<1083:SMODFB>2.0.ZU;2-0
Abstract
DNA fragments are modified with high efficiency (80-90%) by alkylating derivatives of oligonucleotides bearing 4(N-2-chloroethyl-N-methylami no)benzyl group at the C5 atom of the terminal or internal deoxyuridin e residue. Target modification at a single point is achieved.