POLYMORPHONUCLEAR LEUKOCYTE MIGRATION RESPONSE IN UNEVENTFUL WOUND-HEALING FOLLOWING TRAUMA SURGERY - A CONTRIBUTION TO THE SEARCH FOR OBJECTIFIABLE CRITERIA IN WOUND-HEALING MONITORING
Hp. Hofer et al., POLYMORPHONUCLEAR LEUKOCYTE MIGRATION RESPONSE IN UNEVENTFUL WOUND-HEALING FOLLOWING TRAUMA SURGERY - A CONTRIBUTION TO THE SEARCH FOR OBJECTIFIABLE CRITERIA IN WOUND-HEALING MONITORING, Archives of orthopaedic and trauma surgery, 113(3), 1994, pp. 170-173
In a study of the clinical importance of polymorphonuclear granulocyte
s (PMN) for the monitoring of wound healing we investigated the postsu
rgical course of nine patients all of whom had undergone trauma surger
y and had no wound complications. The ''stimulated random PMN locomoti
on'' was evaluated by a new migration filter device which preserves th
e cells in their genuine priming state, simulating in vivo conditions.
The percentage of all activated PMN, expressed by the total migration
index (TMI) reflected the highest median immediately after surgery (z
(max) = 30.1%) and dropped to the lowest value on day 13 (z(min) = 13.
9%). The mean invasion depth (T/2) of the cells along the migration di
stance into the filter showed only slight variations over time. The ne
utrophil migration activity (NMA), described by T/2 and TMI, behaved i
n a similar way to TMI. In studying physiological healing, preliminary
results indate that TMI, which expresses PMN activation, is an effici
ent tool in the postoperative monitoring of patients, and might in the
future serve as a basis for an early warning system for wound healing
complications.