POLYMORPHONUCLEAR LEUKOCYTE MIGRATION RESPONSE IN UNEVENTFUL WOUND-HEALING FOLLOWING TRAUMA SURGERY - A CONTRIBUTION TO THE SEARCH FOR OBJECTIFIABLE CRITERIA IN WOUND-HEALING MONITORING

Citation
Hp. Hofer et al., POLYMORPHONUCLEAR LEUKOCYTE MIGRATION RESPONSE IN UNEVENTFUL WOUND-HEALING FOLLOWING TRAUMA SURGERY - A CONTRIBUTION TO THE SEARCH FOR OBJECTIFIABLE CRITERIA IN WOUND-HEALING MONITORING, Archives of orthopaedic and trauma surgery, 113(3), 1994, pp. 170-173
Citations number
16
Categorie Soggetti
Orthopedics,Surgery
ISSN journal
09368051
Volume
113
Issue
3
Year of publication
1994
Pages
170 - 173
Database
ISI
SICI code
0936-8051(1994)113:3<170:PLMRIU>2.0.ZU;2-N
Abstract
In a study of the clinical importance of polymorphonuclear granulocyte s (PMN) for the monitoring of wound healing we investigated the postsu rgical course of nine patients all of whom had undergone trauma surger y and had no wound complications. The ''stimulated random PMN locomoti on'' was evaluated by a new migration filter device which preserves th e cells in their genuine priming state, simulating in vivo conditions. The percentage of all activated PMN, expressed by the total migration index (TMI) reflected the highest median immediately after surgery (z (max) = 30.1%) and dropped to the lowest value on day 13 (z(min) = 13. 9%). The mean invasion depth (T/2) of the cells along the migration di stance into the filter showed only slight variations over time. The ne utrophil migration activity (NMA), described by T/2 and TMI, behaved i n a similar way to TMI. In studying physiological healing, preliminary results indate that TMI, which expresses PMN activation, is an effici ent tool in the postoperative monitoring of patients, and might in the future serve as a basis for an early warning system for wound healing complications.