DETECTION OF C-13-LABELED METABOLITES IN THE IN-VIVO CANINE HEART BY B-1 INSENSITIVE HETERONUCLEAR COHERENT POLARIZATION TRANSFER AND COMPARISON OF SIGNAL ENHANCEMENT WITH NOE

A recently developed adiabatic coherent polarization transfer enhancem ent technique [H. Merkle, H, Wei, M. Garwood, K. Ugurbil. J. Magn. Res on. 99, 480-494 (1992)] was employed to perform C-13 spectroscopy in t he intact canine heart in vivo during [2-C-13]-acetate infusion into t he left descending coronary artery; the results were compared with C-1 3 spectra obtained with conventionally employed nuclear Overhauser enh ancement, The results demonstrate that both methods can be performed b y using surface coils to obtain in vivo C-13 spectra and that coherent polarization transfer provides better enhancement than NOE for [2-C-1 3]-acetate but not for short T-2 compounds.