ELECTRIC-CURRENT DENSITY IMAGING OF MICE-TUMORS

The use of electric current density imaging (CDI) to map spatial distr ibution of electric currents through tumors is presented, Specifically , a method previously tested on phantoms was implemented in vivo and i n vitro for mapping electric current pulses of the same order of magni tude (j congruent to 2500 A/m(2)) as in electrochemotherapy through T5 0/80 mammary carcinomas, B-16 melanomas and SA-1 sarcomas, A technical ly simplified method of electric current density imaging is discussed as well, Three geometries of electrodes (flat-flat, point-point, point -flat) indicate altered electric current distribution for the same tum or. This indicates that the method can be used for monitoring the effe cts of electrochemotherapy as a function of electrode geometry.