Antecedent variables under the broad categories of genetic, environmen
tal and cultural influences have been linked to the risk for alcohol a
buse. Such risk factors have not been shown to result in high correlat
ions with alcohol consumption and leave unclear an understanding of th
e mechanism by which these variables lead to increased risk. This stud
y employed covariance structure modeling to examine the mediational in
fluence of stored information in memory about alcohol, alcohol expecta
ncies in relation to two biologically and environmentally driven antec
edent variables, family history of alcohol abuse and a sensation-seeki
ng temperament in a college population. We also examined the effect of
criterion contamination on the relationship between sensation-seeking
and alcohol consumption. Results indicated that alcohol expectancy ac
ts as a significant, partial mediator of the relationship between sens
ation-seeking and consumption, that family history of alcohol abuse is
not related to drinking outcome and that overlap in items on sensatio
n-seeking and alcohol consumption measures may falsely inflate their r
elationship.