2-STEP TCR-ZETA CD3-CD4 AND CD28 SIGNALING IN T-CELLS - SH2/SH3 DOMAINS, PROTEIN-TYROSINE AND LIPID KINASES/

A central question in T-cell immunity concerns the nature of intracell ular signaling from the antigen receptor, the CD4/CD8 co-receptors and the CD28 antigen. Since the original discovery that T-cell receptors such as CD4 can interact with intracellular protein-tyrosine Kinases s uch as p56(lck), remarkable progress has been made in deciphering the signaling pathways that control T-cell growth and immune function. Her e, Christopher Rudd and colleagues examine the role of protein-tyrosin e kinases, SH2/SH3 domains and lipid kinases in the generation of sign als from the TCR zeta/CD3 complex and the CD28 antigen.