THE MIGRATION, PHAGOCYTOSIS AND REDUCTION ABILITY OF GRANULOCYTES FROM SKIN INFILTRATIONS OF PATIENTS WITH ATOPIC ASTHMA

The migration, phagocytosis and reduction ability of granulocytes from the skin of atopic asthmatics (n = 30) and healthy control subjects ( n = 20) were evaluated. In all subjects, granulocyte migration was eva luated in vitro using the Clausen test and in vivo using the Matusiewi cz and Brzezinska test, and Park's tests of phagocytosis of neutral la tex particles and the reduction of nitroblue tetrazolium (NBT) were al so performed It was demonstrated that patients with atopic asthma had a defect in skin granulocyte migration. Our studies also showed that t he ability of granulocytes from skin infiltrations to reduce NBT was i ncreased. The ability of granulocytes from skin infiltrations to migra te was inversely proportional to the degree of oxidative burst in pati ents with atopic asthma.