Levels of heparin cofactor II (HCII) activity and antigen and electrop
horetic pattern were studied both in normal subjects and in type I dia
betic patients with high and normal levels of glycosylated haemoglobin
. There was a significant reduction in HCII activity (83 +/- 7%) in pa
tients with high levels of glycosylated haemoglobin compared with cont
rols (95 +/- 17%; P < 0.001). However, plasma HCII antigen levels were
not decreased in these patients.