DETERMINATION OF THE ALLELIC AND HAPLOTYPE FREQUENCIES OF 3 POLYMORPHISMS IN THE PROMOTER REGION OF THE HUMAN PROTEIN-C GENE

Authors
SPEK CA POORT SR BERTINA RM REITSMA PH
Citation
Ca. Spek et al., DETERMINATION OF THE ALLELIC AND HAPLOTYPE FREQUENCIES OF 3 POLYMORPHISMS IN THE PROMOTER REGION OF THE HUMAN PROTEIN-C GENE, Blood coagulation & fibrinolysis, 5(2), 1994, pp. 309-311
Citations number
10
Categorie Soggetti
Hematology
Journal title
Blood coagulation & fibrinolysis → ACNP
ISSN journal
09575235
Volume
5
Issue
2
Year of publication
1994
Pages
309 - 311
Database
ISI
SICI code
0957-5235(1994)5:2<309:DOTAAH>2.0.ZU;2-#
Abstract
The frequencies of three polymorphisms in the promoter region of the h uman protein C gene (C/T at - 1654, A/G at - 1641 and A/T at -1476) ha ve been determined. All three polymorphisms show allelic frequencies o f about 0.60 and 0.40. The determination of the frequencies of the hap lotypes of these polymorphisms showed that three of them (CGT, TAA and CAA) account for 88% of the observed haplotypes.