POSTMORTEM BRAINS REVEAL SIMILAR BUT NOT IDENTICAL AMYLOID PRECURSOR PROTEIN-LIKE IMMUNOREACTIVITY IN ALZHEIMER COMPARED WITH OTHER DEMENTIAS

Authors
WEBSTER MT FRANCIS PT PROCTER AW STRATMANN GC DOSHI R MANN DMA BOWEN DM
Citation
Mt. Webster et al., POSTMORTEM BRAINS REVEAL SIMILAR BUT NOT IDENTICAL AMYLOID PRECURSOR PROTEIN-LIKE IMMUNOREACTIVITY IN ALZHEIMER COMPARED WITH OTHER DEMENTIAS, Brain research, 644(2), 1994, pp. 347-351
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
644
Issue
2
Year of publication
1994
Pages
347 - 351
Database
ISI
SICI code
0006-8993(1994)644:2<347:PBRSBN>2.0.ZU;2-3
Abstract
Concentrations of amyloid precursor protein (APP)-like immunoreactivit y (APPLIR) have been determined by Western blotting in a soluble fract ion and two membrane fractions of two areas of brain cortex from patie nts with Alzheimer's disease (AD) and other dementias. There were no s ignificant differences between AD and other cases in species with the Kunitz protease inhibitor domain. However, the total soluble APPLIR wa s higher in AD and it was hypothesized that this relates to cholinergi c hypoactivity.