THE PHOTOCHEMISTRY OF METYRAPONE IN THE SOLID-STATE

Authors
FASANI E MELLA M ALBINI A
Citation
E. Fasani et al., THE PHOTOCHEMISTRY OF METYRAPONE IN THE SOLID-STATE, Chemical and Pharmaceutical Bulletin, 45(2), 1997, pp. 394-396
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
2
Year of publication
1997
Pages
394 - 396
Database
ISI
SICI code
0009-2363(1997)45:2<394:TPOMIT>2.0.ZU;2-5
Abstract
Metyrapone (2-methyl-1,2-di-3-pyridyl-1-propanone) undergoes alpha-cle avage upon irradiation in the solid state. The reaction occurs at the crystal surface, and the radicals formed in part recombine to give dip yridylketones, and in part add oxygen to give nicotinic acid and 3-(1- hydroxymethylethyl)pyridine. The crystals partially melt and the react ion continues until complete decomposition of the starting material.