Jk. Bashkin et al., SYNTHESIS AND CONNECTIVITY ASSIGNMENT (BY 2D-NMR) OF A NUCLEOSIDE-DIPEPTIDE - YL]AMINO]ETHYL]AMINO]-3-OXOPROPYL]-2'-DEOXYURIDINE, New journal of chemistry, 18(3), 1994, pp. 305-316
The synthesis of VI, a 2'-deoxyuridine derivative with a His-His dipep
tide covalently attached at the pyrimidine C-5 position through a link
er arm, is reported. The title compound is designed to serve as a buil
ding block for catalytic nucleic acids, or synthetic ribozymes, and wa
s prepared in five steps from 2-amino-ethyl)amino]-3-oxopropyl]-2'-deo
xyuridine. The complete connectivity assignment of VI and extensive NM
R assignment of the intermediates II-V by the use of 1- and 2-DNMR are
reported.