SYNTHESIS OF A NEW POTENT ANTI-ANGIOGENIC AGENT, -ACETOXY-9-ALPHA-FLUORO-6-ALPHA-METHYLPROGESTERONE (9-ALPHA-FLUOROMEDROXYPROGESTERONE ACETATE [FMPA])

Authors
SUGINO E FUJIMORI S HIBINO S CHOSHI T ICHIHARA Y SATO Y YAMAJI T TSUBOI H MURATA N UCHIDA M SHIMAMURA M OIKAWA T
Citation
E. Sugino et al., SYNTHESIS OF A NEW POTENT ANTI-ANGIOGENIC AGENT, -ACETOXY-9-ALPHA-FLUORO-6-ALPHA-METHYLPROGESTERONE (9-ALPHA-FLUOROMEDROXYPROGESTERONE ACETATE [FMPA]), Chemical and Pharmaceutical Bulletin, 45(2), 1997, pp. 421-423
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
2
Year of publication
1997
Pages
421 - 423
Database
ISI
SICI code
0009-2363(1997)45:2<421:SOANPA>2.0.ZU;2-J
Abstract
A new anti-angiogenic agent, 17 alpha-acetoxy-9 alpha-fluoro-6 alpha-m ethylprogesterone (9 alpha-fluoromedoroxyprogesterone acetate [FMPA, 9 ]) was synthesized in a 10-step sequence. FMPA (9) had about two order s of magnitude stronger antiangiogenic activity than medroxyprogestero ne acetate (MPA), as estimated in a bioassay involving chorioallantoic membranes of growing chick embryos.