ROLE OF THE HYDROPHOBIC MOIETY OF TUMOR PROMOTERS - SYNTHESIS AND ACTIVITY OF BENZOLACTAMS WITH ALKYL SUBSTITUENTS AT VARIOUS POSITIONS

Authors
ENDO Y OHNO M TAKEHANA S DRIEDGER PE STABEL S SHUDO K
Citation
Y. Endo et al., ROLE OF THE HYDROPHOBIC MOIETY OF TUMOR PROMOTERS - SYNTHESIS AND ACTIVITY OF BENZOLACTAMS WITH ALKYL SUBSTITUENTS AT VARIOUS POSITIONS, Chemical and Pharmaceutical Bulletin, 45(2), 1997, pp. 424-426
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
2
Year of publication
1997
Pages
424 - 426
Database
ISI
SICI code
0009-2363(1997)45:2<424:ROTHMO>2.0.ZU;2-E
Abstract
We synthesized benzolactams with hydrophobic substituents at various p ositions as analogs of (-)-benzolactam-V8-310 ((-)-BL-V8-310, 1) which reproduces the active conformation and biological activity of teleoci dins. Structure-activity data indicate that the existence of a hydroph obic region between C-2 and C-9, and the steric factor at C-8 play cri tical roles in the appearance of biological activities.