Heavy ion reactions in the sub-barrier region are of interest for the
importance of C-12 + C-12, C-12 + O-16 and O-16 + O-16 in astrophysics
. Systematic studies of the light heavy ion pairs are necessary to und
erstand the interaction potentials. In this article, different experim
ental techniques are reviewed. Theoretical approaches such as the opti
cal model, IWBC model and the inversion method are discussed. Up to th
is day, no theoretical method gives satisfactory explanation to the he
avy ion systems. More experimental works are still needed in order to
reveal the influence of nuclear structure in the reaction mechanism.