J. Cervosnavarro et al., NEUROPATHOLOGICAL CHANGES FOLLOWING OCCLUSION OF THE SUPERIOR SAGITTAL SINUS AND CEREBRAL VEINS IN THE CAT, Neuropathology and applied neurobiology, 20(2), 1994, pp. 122-129
Superior sagittal sinuses (SSS) of 36 mongrel cats were occluded by po
lymer injection. Immediately prior to the occlusion, Evans-blue (EB) w
as administered intravenously. The cats were killed 1, 3, 6, 12, 24, 7
2 and 120 h after sinus occlusion. Two sham-operated cats were killed
6 h and two 120 h after the operation. In 16 cats in which the occlusi
on was limited to the SSS, as well as in the sham-operated cats, no EB
extravasation was present. However, ultrastructurally in two animals,
the extracellular spaces were moderately enlarged, corresponding to i
ncreased permeability for water without opening of the BBB for protein
s. In 20 cats in which cortical veins were occluded, in addition to th
e SSS, EB was extravasated. In nine of these cats, which had moderate
oedema, EB-staining was present only in the cortex. In 11 cats with se
vere oedema, massive EB extravasation was observed also in the white m
atter. The U-fibre layer was free of EB, suggesting that the extension
of oedema was blocked by this zone. Cats with severe oedema showed ex
tensive haemorrhagic cerebral infarction widely, but not completely, o
verlapping with ischaemic necrosis, and corresponding to the differenc
es in the territories of arterial supply and of venous drainage. Seven
animals displayed haematomas in the parasagittal white matter. Electr
on microscopy (EM) showed damage to the endothelium of capillaries and
venules with extravasation of platelets. In cats which survived longe
r than 24 h, the extracellular spaces were filled with proteinaceous t
ransudate. Gliosis of the affected grey and white matter was observed
in cats examined 24, 72 and 120 h after occlusion. Notwithstanding the
differences between this model and human cerebral sinus and vein thro
mbosis, the procedure represents an experimental approach to understan
ding the variability of the clinical course in patients with thrombosi
s of SSS. The results stress the role of the occlusion of the cortical
veins in the extension of brain damage.