NAFTIDROFURYL FOR THE PREVENTION OF PERIP HERAL NEUROPATHY INDUCED BYVINCRISTINE - A RANDOMIZED PLACEBO-CONTROLLED STUDY IN 29 PATIENTS

Naftidrofuryl is a specific 5-HT2 receptor antagonist used since 1968 as a cardiovascular agent. Studies of rat spinal ganglion cultures hav e established that naftidrofuryl has effects on nerve growth. This stu dy was conducted to evaluate naftidrofuryl for the prevention of perip heral neuropathy induced by vincristine sulfate. The study included 29 patients with lymphoid malignancies treated by combination chemothera py including intravenous vincristine in a mean dose of 10.98 mg. Thirt een patients were randomized to oral naftidrofuryl in a dose of 600 mg /d and 16 were randomized to a placebo. Both treatments were given fro m the first day of the chemotherapy course to the eighth day after the end of the chemotherapy course. Double-blind evaluation of clinical a nd electrophysiological criteria showed that the only significant diff erences were decreased in the number and severity of polyneuropathies in naftidrofuryl patients as compared with control group. These data r equire confirmation by further clinical studies in humans.