Between 1958 and 1990 67 patients with an early glottic carcinoma invo
lving the anterior commissure were treated by radiotherapy. Excluding
three with carcinoma in situ, 64 had a T1N0M0 squamous cell carcinoma;
in eight of these (12.5%) the tumour was only located in the anterior
commissure, in 45 (70.3%) it also involved one vocal cord and in 11 (
17.2%) both vocal cords. The overall 5-year survival rate was 85%. For
those with only anterior commissure involvement it was 60%, with invo
lvement of one vocal cord and the anterior commissure it was 89% and w
ith involvement of both vocal cords 82%. The 3-year recurrence rate wa
s 58% for patients with involvement of only the anterior commissure, 2
4% with involvement also of one vocal cord, and 45% for those with inv
olvement of both vocal cords. It was found that in cases of early glot
tic carcinoma, involving the anterior commissure and treated by radiot
herapy, the prognosis for recurrence and survival was poorest when the
carcinoma was only located in the anterior commissure, and it was con
cluded that this group of patients deserves special consideration.