DETERMINATION OF VALPROATE IN THE PRESENCE OF FELBAMATE IN HUMAN PLASMA BY NARROW-BORE CAPILLARY GAS-CHROMATOGRAPHY

Authors
ROMANYSHYN LA WAGNER MC WICHMANN JK KUCHARCZYK N SOFIA RD
Citation
La. Romanyshyn et al., DETERMINATION OF VALPROATE IN THE PRESENCE OF FELBAMATE IN HUMAN PLASMA BY NARROW-BORE CAPILLARY GAS-CHROMATOGRAPHY, Epilepsia, 35(2), 1994, pp. 406-410
Citations number
13
Categorie Soggetti
Clinical Neurology
Journal title
Epilepsia → ACNP
ISSN journal
00139580
Volume
35
Issue
2
Year of publication
1994
Pages
406 - 410
Database
ISI
SICI code
0013-9580(1994)35:2<406:DOVITP>2.0.ZU;2-K
Abstract
A narrow bore capillary gas chromatographic method with one extraction step has been developed for quantitation of valproate (VPA) in the pr esence of felbamate (FBM) in human plasma. The method uses 0.250-ml al iquots of human plasma and one internal standard (IS). Chromatographic conditions include a DBWAX, 0.25 mm ID x 15 m, 0.25-mu m film thickne ss column; splitless injection; and flame ionization detection. The li near quantitation range for VPA is 1.00-256 mu g/ml.