IS TREATMENT OF LONG-TERM AND CONSECUTIVE USE OF CLOMIPHENE CITRATE EFFECTIVE IN ANOVULATORY PATIENTS - RESULTS OF MULTI-CENTRIC RETROSPECTIVE STUDIES

The efficacy of long term consecutive treatment of clomiphene citrate (CC) was investigated in 608 infertile women associated with anovulato ry disorders (classified as WHO group II amenorrhea). This study was p erformed in multi-centric facilities of obstetrics and gynecology by a retrospective randomized assessment. Infertile women associated with anovulation were treat ed by 50-150 mg of CC for five consecutive days in each treatment cycle. In this study, 200 pregnancies were observed and the total pregnancy rate was 32.9%. The number of abortions were 33 out of the 200 pregnancies (16.5%). The cumulative pregnancy rate w ithin the pregnant subjects reached 90% in initial 10 treatment cycles and there was no difference between 50 mg and 100 mg of CC treatment. There were remarkable differences among the pregnancy rates achieved during consecutive treatments at the primary (clinics and hospital), s econdary (regional center hospitals) and advanced facilities. Consecut ive treatment by CC for infertile women associated with anovulation ma y be effective during initial 10 cycles. Although ovulation can be con firmed during the following cycles, the stimulation protocol should be reconsidered after 12 consecutive cycles therapy with CC, because cyc le fecundity decreases. Hence, to improve pregnancy rates, it is impor tant to check the previous administration of CC which reflects adverse ly on the subsequent conception rate especially in advanced facilities where these patients are reffered to.