HYPOCHOLESTEROLEMIC EFFECTS OF A DIETARY FIBER SUPPLEMENT

Citation
Db. Hunninghake et al., HYPOCHOLESTEROLEMIC EFFECTS OF A DIETARY FIBER SUPPLEMENT, The American journal of clinical nutrition, 59(5), 1994, pp. 1050-1054
Citations number
16
Categorie Soggetti
Nutrition & Dietetics
ISSN journal
00029165
Volume
59
Issue
5
Year of publication
1994
Pages
1050 - 1054
Database
ISI
SICI code
0002-9165(1994)59:5<1050:HEOADF>2.0.ZU;2-8
Abstract
The cholesterol-lowering effects of a fiber supplement were evaluated in patients with mild to moderate hypercholesterolemia. After a 9-wk d iet stabilization period, patients were randomly assigned to treatment with 10 or 20 g/d of the fiber supplement or with a matching placebo. Among patients who completed the 15-wk treatment period, total choles terol, LDL cholesterol, and the ratio of LDL to HDL (LDL/HDL) were sig nificantly reduced (P < 0.05) for the 10- (n = 40) and 20-g/d (n = 39) groups compared with the placebo group (n = 48). In the placebo group and 10- and 20-g/d groups, the percent changes in total cholesterol w ere 0.4%, -5.8%, and -4.9%, in LDL cholesterol were -0.4%, -8.1%, and -7.3%, and in LDL/HDL were 1.0%, -5.6%, and -8.7%, respectively. The f iber supplement had no significant effects (P > 0.05) on HDL cholester ol or triglycerides. The changes in lipoprotein concentrations could n ot be attributed to changes in diet or body weight because there were no significant changes in these variables during the 15-wk treatment p eriod.