Br. Karlsson et al., THE SEVERITY OF POSTISCHEMIC HYPOPERFUSION INCREASES WITH DURATION OFCEREBRAL-ISCHEMIA IN RATS, Acta anaesthesiologica Scandinavica, 38(3), 1994, pp. 248-253
Regional cerebral blood flow was studied after a period of hypotensive
bilateral carotid occlusion in rats. As other studies have found, we
confirm that 15 min of ischemia caused an initial brief hyperemic epis
ode followed by severe hypoperfusion in all areas. With varying durati
on of ischemia from 5 to 10, 15 and 20 min, the median cerebral blood
flow 60 min postischemia was 79%, 46%, 48% and 34% of control, respect
ively. Thus the degree of postischemic hypoperfusion increased signifi
cantly with the duration of ischemia.