INDICATION FOR ANTIEPILEPTIC DRUG-TREATMENT OF BENIGN CHILDHOOD EPILEPSY WITH CENTRO-TEMPORAL SPIKES

To approach the problem concerning whether or not anti-epileptic treat ment of benign childhood epilepsy with centro-temporal spikes (BCECT) is necessary, we retrospectively studied 6 untreated and 39 treated pa tients with BCECT and compared their clinical findings after 2 years o f observation. Then we selected 6 untreated and 28 treated patients fr om the same series who had been free from attacks for more than 2 year s to determine whether the mode of onset (multiple seizures or isolate d one for the first month of the illness) was related to the duration of active epilepsy in these two groups. This comparative study of untr eated and treated patients followed for 2 years revealed no difference s in the interval between first visit and start of attack-free period between the two groups. The mean duration of active epilepsy in those with only isolated seizures at onset was significantly shorter than th at in those with multiple seizures at onset. Anti-epileptic medication may be unnecessary in patients with isolated seizure during sleep; it does not affect the natural course of BCECT. Treatment is necessary f or a longer period in patients with multiple seizures at onset than in those with isolated seizures at onset.