RESULTS OF THE ADMINISTRATION OF BISPHOSPHONATES FOR THE PREVENTION OF PERIOSTEAL BONE-FORMATION FOLLOWING MOLONEY SARCOMA VIRUS-INDUCED TUMORS

Authors
WLODARSKI P WLODARSKI K GALUS K LUCZAK M
Citation
P. Wlodarski et al., RESULTS OF THE ADMINISTRATION OF BISPHOSPHONATES FOR THE PREVENTION OF PERIOSTEAL BONE-FORMATION FOLLOWING MOLONEY SARCOMA VIRUS-INDUCED TUMORS, Folia biologica, 39(6), 1993, pp. 297-303
Citations number
25
Categorie Soggetti
Biology
Journal title
Folia biologica → ACNP
ISSN journal
00155500
Volume
39
Issue
6
Year of publication
1993
Pages
297 - 303
Database
ISI
SICI code
0015-5500(1993)39:6<297:ROTAOB>2.0.ZU;2-4
Abstract
The effect of continuous and discontinuous administration of bisphosph onates on the periosteal osteogenesis induced by Moloney sarcoma devel opment was studied in mice by histological examination and bone dry ma ss evaluation. Both EHDP and Cl(2)MDP did not inhibit periosteal osteo genesis but EHDP, in contrast to Cl(2)MDP, inhibited the mineralizatio n of osteoid. This inhibition was completely reversible after the with drawal of the drug. Within two weeks the remineralization of newly for med bone matrix was completed.