The hierarchical linear model approach to a two-level design is consid
ered, some variables at the lower level having fixed and others having
random regression coefficients. An approximation is derived to the co
variance matrix of the estimators of the fixed regression coefficients
(for variables at the lower and the higher level) under the assumptio
n that the sample sizes at either level are large enough. This covaria
nce matrix is expressed as a function of parameters occurring in the m
odel. If a research planner can make a reasonable guess as to these pa
rameters, this approximation can be used as a guide to the choice of s
ample sizes at either level.