A PROSPECTIVE, RANDOMIZED STUDY OF PEFLOXACIN VERSUS TEICOPLANIN IN THE TREATMENT OF GRAM-POSITIVE COCCAL INFECTIONS IN CANCER-PATIENTS - EARLY TERMINATION DUE TO EMERGENCE OF RESISTANCE TO FLUOROQUINOLONES

Authors
AOUN M VANDERAUWERA P VARTHALITIS I BOURGUIGNON AM JANSSEN M DANEAU D MEUNIER F
Citation
M. Aoun et al., A PROSPECTIVE, RANDOMIZED STUDY OF PEFLOXACIN VERSUS TEICOPLANIN IN THE TREATMENT OF GRAM-POSITIVE COCCAL INFECTIONS IN CANCER-PATIENTS - EARLY TERMINATION DUE TO EMERGENCE OF RESISTANCE TO FLUOROQUINOLONES, Supportive care in cancer, 2(3), 1994, pp. 191-196
Citations number
29
Categorie Soggetti
Oncology,Rehabilitation,"Medicine, General & Internal
Journal title
Supportive care in cancer → ACNP
ISSN journal
09414355
Volume
2
Issue
3
Year of publication
1994
Pages
191 - 196
Database
ISI
SICI code
0941-4355(1994)2:3<191:APRSOP>2.0.ZU;2-A
Abstract
A randomized prospective study comparing pefloxacin to teicoplanin in the treatment of gram-positive infections in cancer patients was prema turely terminated because of the emergence of pefloxacin resistance as sociated with oxacillin resistance in Staphylococcus aureus and coagul ase-negative staphylococci. Among 56 patients evaluated for efficacy ( 26 pefloxacin and 30 teicoplanin) and infected with bacteria susceptib le to both antibiotics, the clinical cure and eradication rates were s imilar for pefloxacin (80.5% and 77.3% respectively) and teicoplanin ( 66.6% and 52.2% respectively). The relapse rates (15% and 10% for pefl oxacin and teicoplanin respectively) and the overall mortalities withi n 1 month (42% and 31%) were similar.