IN-VITRO ANTIPROLIFERATIVE ACTIVITY OF DOCETAXEL (TAXOTERE(R)), PACLITAXEL (TAXOL(R)) AND CISPLATIN AGAINST HUMAN TUMOR AND NORMAL BONE-MARROW CELLS

The in vitro antiproliferative effect of docetaxel (Taxotere(R)), pacl itaxel (Taxol(R)) and cisplatin was assessed in a range of human tumou r types, including 25 tumour cell lines and 35 primary cultures. Addit ionally, 12 human normal bone marrow samples were analyzed. Seven labo ratories, all members of the EORTC Preclinical Therapeutic Models Grou p (PTMG), have performed these tests, using their own individual assay procedures. In all comparisons docetaxel and paclitaxel were much mor e potent than cisplatin with IC50 values of the taxoids being in the n anomolar range. Docetaxel generally was two- to four-fold more cytotox ic than paclitaxel. The sensitivity profile of the cell lines, which w as based on the IC50 values, indicated a certain degree of cross-sensi tivity between paclitaxel and docetaxel (linear regression analysis; r =0.73, p < 0.001). On the other hand, the sensitivity profile of cispl atin was different from the ones seen for docetaxel and paclitaxel, in dicating that no cross-sensitivity exists between cisplatin and both t axoids.