Rp. Liberman et al., OPTIMAL DRUG AND BEHAVIOR-THERAPY FOR TREATMENT-REFRACTORY SCHIZOPHRENIC-PATIENTS, The American journal of psychiatry, 151(5), 1994, pp. 756-759
Thirteen treatment-refractory schizophrenic patients (10 melt and thre
e women) who were receiving more than 50 mg/day of haloperidol and who
had been hospitalized for more than 1 year successfully tolerated a m
ean dose reduction of 63% with consequent improvement in psychopatholo
gy and side effects. The addition of intensive behavior therapy to the
optimal dose of haloperidol yielded further improvements in functiona
l behavior, such as self-care and social interaction,