Objective To assess the factors associated with loss of implant follow
ing penile prosthetic surgery and to make alterations in the managemen
t of patients to prevent this from occurring. Patients and methods A r
etrospective analysis was carried out of the factors associated with p
ost-operative infection and erosion in 188 patients who underwent impl
antation of penile prostheses. A prospective study was then establishe
d in which 62 patients were managed by a set protocol designed to coun
teract the factors identified as being contributory to loss of implant
s in the retrospective review. Results In the retrospective study nine
(4.8%) patients lost a prosthesis due to erosion. Erosion was noted t
o be more common with one type of implant which has since been modifie
d. Infection was the cause of prosthesis loss in 12.2% of patients in
the retrospective review. The new protocol resulted in a significantly
reduced infection rate in penile prostheses to 1.6% (P < 0.05). Concl
usion With attention to simple antiseptic prophylaxis, antibiotic pene
tration and continuing audit, a significant improvement in the loss of
penile prostheses can be achieved along with a reduction in the amoun
t of antibiotics prescribed.