SYNERGISTIC EFFECT OF CEFOTAXIME AND NORMAL HUMAN SERUM ON BACTERICIDAL ACTIVITY AGAINST URINARY STRAINS OF ESCHERICHIA-COLI WITH CAPSULAR ANTIGEN K1

Authors
FRANICZEK R JANKOWSKI S
Citation
R. Franiczek et S. Jankowski, SYNERGISTIC EFFECT OF CEFOTAXIME AND NORMAL HUMAN SERUM ON BACTERICIDAL ACTIVITY AGAINST URINARY STRAINS OF ESCHERICHIA-COLI WITH CAPSULAR ANTIGEN K1, Acta Microbiologica Polonica, 42(3-4), 1993, pp. 243-250
Citations number
NO
Categorie Soggetti
Microbiology
Journal title
Acta Microbiologica Polonica → ACNP
ISSN journal
01371320
Volume
42
Issue
3-4
Year of publication
1993
Pages
243 - 250
Database
ISI
SICI code
0137-1320(1993)42:3-4<243:SEOCAN>2.0.ZU;2-W
Abstract
About 11 % of Escherichia coli strains isolated from patients with uri nary tract infections produced capsular antigen K1. In a group of stra ins resistant to normal human serum the percentage of strains with K1 antigen was higher than that without this antigen. Cefotaxime and seru m showed synergistic action in the bactericidal reaction against E. co li strains resistant to the serum. Lack of synergistic effect of therm ally inactivated serum with subminimal concentrations of cefotaxime in dicated participation of complement in this reaction.The antibiotic us ed in subminimal concentrations caused significant elongation of E. co li bacilli.